CEFTEZOLE SODIUM

CEFTEZOLE SODIUM
PRODUCT IDENTIFICATION
CAS NO.	26973-24-0 (parent) 41136-22-5 (sodium)
EINECS NO.
FORMULA	C₁₃H₁₁N₈O₄S₃·Na
MOL WT.	462.45
H.S. CODE	2941.90.5000
TOXICITY	Oral Rat LD50: > 20gm/kg
SYNONYMS	Ceftezole sodium; Alomen; Celoslin; Falomesin;
Sodium (6R-trans)-8-oxo-7-((1H-tetrazol-1-ylacetyl)amino)-3 -((1,3,4-thiadiazol-2 -ylthio) methyl)- 5-thia-1-azabicyclo(4.2.0)oct-2-ene-2- carboxylate; (6R-trans)-8-Oxo-7-((1H-tetrazol-1-ylacetyl)amino )-3-((1,3,4-thiadiazol-2-ylthio) methyl)-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid monosodium salt; Ceftezol;
SMILES	[Na+].N12C(=C(CS[C@@H]2[C@@H](C1=O)NC(=O)Cn1nnnc1) CSc1scnn1)C(=O)[O-]
CLASSIFICATION	Antiboitics / Cephalosporins /
EXTRA NOTES	1st generation cephalosporin
PHYSICAL AND CHEMICAL PROPERTIES
PHYSICAL STATE	white to yellowish crystalline powder
MELTING POINT
BOILING POINT
SPECIFIC GRAVITY
SOLUBILITY IN WATER	313 mg/l at 25 C
pH
VAPOR DENSITY
AUTOIGNITION
log P	-0.67 (Octanol-water)
VAPOR PRESSURE	3.63E-18 (mmHg at 25 C)
HENRY LAW CONSTANT	1.82E-23 (atm-m3/mole at 25 C)
OH RATE CONSTANT	1.27E-10 (cm3/molecule-sec at 25 C Atmospheric)
NFPA RATINGS	Health hazard: 2, Fire: 0, Reactivity Hazard: 0
REFRACTIVE INDEX
FLASH POINT
STABILITY	Stable under ordinary conditions.
EXTERNAL LINKS & GENERAL DESCRIPTION
Wikipedia Linking Google Scholar Search Drug Information Portal (U.S. National Library of Medicine) - CEFTEZOLE PubChem Compound Summary - CEFTEZOLE http://www.ncbi.nlm.nih.gov/ Ceftezole, a new cephalosporin C derivative II. Distribution and excretion in parenteral administration. http://www.spandidos-publications.com/ Ceftezole, a cephem antibiotic, is an ��-glucosidase inhibitor with in vivo anti-diabetic activity http://aac.asm.org/ The susceptibilities of 52 clinical isolates of Bacteroides fragilis to five monoanionic cephalosporins were examined. Cefoperazone showed the highest antibacterial activity, followed by ceftezole, cefazolin, cefamandole, and cephalothin. There were two groups of resistant strains: one group (ca. 15%), of which B. fragilis G-232 was a typical sample, was resistant to ceftezole (MIC, 100 uig/ml), cefazolin (MIC, 100 ,g/nl), and cephalothin (MIC, 200 ,ug/ml) but not cefoperazone (MIC, 6.25 jLg/ml) or cefamandole (MIC, 25 ,ug/ml). On the basis of studies of stability to ,B-lactamase, outer membrane permeation, and affinity for penicillin-binding proteins (PBPs), we conclude that decreased affinity for PBP 3 may play an i mportant role in the resistance to ceftezole, cefazolin, and cephalothin in B. fragilis G-232. Another group (also ca. 15%), of which B. fragilis G-242 was a representative, was resistant to all five cephalosporins (MIC, 100 to 400 ,ug/ml) and produced a high amount of ,B-lactamase. Similar broad-spectrum resistance was seen in a mutant of strain G-232 that had a greater-than-30-fold increase in P-lactamase production.
SALES SPECIFICATION
APPEARANCE	White to yellowish crystalline powder
ASSAY	860��/�� min
LOSS ON DRYING	5.0% max
SPECIFIC ROTATION	-5° ~ -9°
pH	4.5 - 6.5
HEAVY METALS	20ppm max
BULK DENSITY	0.4g/��
TRANSPORTATION
PACKING
HAZARD CLASS
UN NO.
SAFETY INFORMATION
Hazard OVERVIEW	Irritant
GHS
SIGNAL WORD	Danger
PICTOGRAMS
HAZARD STATEMENTS	H317 May cause an allergic skin reaction H319 Causes serious eye irritation H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled
PRECAUTIONARY STATEMENTS	P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P280 Wear protective gloves/protective clothing/eye protection/face protection. P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P342 + P311 IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
EC DIRECTIVES
HAZARD CODES	Xn Harmful
RISK PHRASES	42/43 May cause sensitization by inhalation and skin contact
SAFETY PHRASES	22 Do not breathe dust 36/37 Wear suitable protective clothing and gloves 45 In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
PRICE INFORMATION